A simple, specific, accurate and precise reverse phase high performance liquid chromatographic method was developed for the simultaneous estimation of valsartan and sacubitril in bulk. The method was developed using an Agilent C18 (4.6*250 mm, 5 μm) column, WATERS HPLC auto sampler, Separation module 2695, PDA detector 996 with a mobile phase containing pH 4.0 phosphate buffer: Acetonitrile (30:70% v/v ) in an isocratic technique with a flow rate of 1.0 ml/min at 254 nm. The retention times were found to be 3.233 min, 2.507 min for valsartan and sacubitril respectively. The proposed method was validated for precision, accuracy, range, linearity, ruggedness and robustness. The calibration curves of the drugs were linear with the correlation coefficient of 0.9996 and 0.9991 for valsartan and sacubitril respectively over the range of 20-100 μg/ml. The method was found to be sensitive and the validation parameters were within the approved limits.
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